Effects of smoking and smoking cessation on endothelial function: 1-year outcomes from a randomized clinical trial.

ABSTRACT:

Objectives

The purpose of this study was to determine whether smoking cessation improves flow-mediated dilation (FMD) of the brachial artery.

Background

The long-term effects of continued smoking and smoking cessation on endothelial function have not been described previously.

Methods

This was a 1-year, prospective, double-blind, randomized, placebo-controlled clinical trial of the effects of 5 smoking cessation pharmacotherapies. FMD was measured by B-mode ultrasonography before and 1 year after the target smoking cessation date. Cessation was verified by exhaled carbon monoxide levels. DeltaFMD was compared among study arms and between subjects who successfully quit smoking and those who continued to smoke. Predictors of baseline FMD and DeltaFMD were identified by

SUBMITTER: Johnson HM 

PROVIDER: S-EPMC2947952 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature