Mechanisms of ATP-dependent nucleosome sliding.

ABSTRACT: Chromatin remodelers are multifunctional protein machines that use a conserved ATPase motor to slide nucleosomes along DNA. Nucleosome sliding has been proposed to occur through two mechanisms: twist diffusion and loop/bulge propagation. A central idea for both of these models is that a DNA distortion propagates over the surface of the nucleosome. Recent data from biochemical and single-molecule experiments have expanded our understanding of histone-DNA and remodeler-nucleosome interactions, and called into question some of the basic assumptions on which these models were originally based. Advantages and challenges of several nucleosome sliding models are discussed.

SUBMITTER: Bowman GD 

PROVIDER: S-EPMC2947954 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature