Widespread over-expression of the X chromosome in sterile F₁hybrid mice.

ABSTRACT: The X chromosome often plays a central role in hybrid male sterility between species, but it is unclear if this reflects underlying regulatory incompatibilities. Here we combine phenotypic data with genome-wide expression data to directly associate aberrant expression patterns with hybrid male sterility between two species of mice. We used a reciprocal cross in which F₁ males are sterile in one direction and fertile in the other direction, allowing us to associate expression differences with sterility rather than with other hybrid phenotypes. We found evidence of extensive over-expression of the X chromosome during spermatogenesis in sterile but not in fertile F₁ hybrid males. Over-expression was most pronounced in genes that are normally expressed after meiosis, consistent with an X chrom

SUBMITTER: Good JM 

PROVIDER: S-EPMC2947990 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature