Smoking and γ-glutamyltransferase: opposite interactions with alcohol consumption and body mass index.

ABSTRACT: Smoking has recently been suggested to synergistically interact with alcohol intake as a determinant of serum gamma-glutamyltransferase (γ-GT), an emergent powerful predictor of disease and mortality. This study investigated whether this also applies to higher smoking and alcohol exposure ranges and to body mass index (BMI), which likewise is strongly associated with γ-GT. Analyses were based on occupational health examinations of more than 15,000 German male workers aged 16-64 years, predominantly from the construction industry. Sociodemographics and other health-related information were collected during the exam. Joint associations of smoking and alcohol consumption or BMI with elevated or log-transformed γ-GT were examined by tabulation and multiple adjusted regression models. Cigarette

SUBMITTER: Breitling LP 

PROVIDER: S-EPMC2948041 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature