The expression of osteopontin and its association with Clara cell 10 kDa protein in allergic rhinitis.

ABSTRACT:

Background

Osteopontin (OPN) is a multifunctional protein that has recently been linked to allergic diseases. Clara cell 10 kDa protein (CC10) is another protein linked to allergy, and has been suggested to have an inhibitory role in inflammatory airway diseases. At this time, it is not known whether OPN is involved in allergic rhinitis (AR) or if there is any association between CC10 and OPN in AR.

Objective

To study the expression of OPN and its potential association with CC10 in AR.

Methods

The expression of CC10 and OPN in nasal mucosa of AR patients was investigated. AR animal models were established by using wild-type and CC10-knockout mice. In some experiments, human recombinant CC10 protein was given to AR mice during either sensitization or challenge. The phe

SUBMITTER: Liu Y 

PROVIDER: S-EPMC2948078 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature