Ontology highlight
ABSTRACT:
SUBMITTER: Gunesdogan U
PROVIDER: S-EPMC2948182 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
Günesdogan Ufuk U Jäckle Herbert H Herzig Alf A
EMBO reports 20100903 10
Despite the fundamental role of canonical histones in nucleosome structure, there is no experimental system for higher eukaryotes in which basic questions about histone function can be directly addressed. We developed a new genetic tool for Drosophila melanogaster in which the canonical histone complement can be replaced with multiple copies of experimentally modified histone transgenes. This new histone-replacement system provides a well-defined and direct cellular assay system for histone func ...[more]