CDNA microarray gene expression profiling of hedgehog signaling pathway inhibition in human colon cancer cells.

ABSTRACT:

Background

Hedgehog (HH) signaling plays a critical role in normal cellular processes, in normal mammalian gastrointestinal development and differentiation, and in oncogenesis and maintenance of the malignant phenotype in a variety of human cancers. Increasing evidence further implicates the involvement of HH signaling in oncogenesis and metastatic behavior of colon cancers. However, genomic approaches to elucidate the role of HH signaling in cancers in general are lacking, and data derived on HH signaling in colon cancer is extremely limited.

Methodology/principal findings

To identify unique downstream targets of the GLI genes, the transcriptional regulators of HH signaling, in the context of colon carcinoma, we employed a small molecule inhibitor of both GLI1 and GLI2, GAN

SUBMITTER: Shi T 

PROVIDER: S-EPMC2948497 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature