The inhibitor of cyclin-dependent kinases, olomoucine II, exhibits potent antiviral properties.

ABSTRACT:

Background

Olomoucine II, the most recent derivative of roscovitine, is an exceptionally potent pharmacological inhibitor of cyclin-dependent kinase activities. Here, we report that olomoucine II is also an effective antiviral agent.

Methods

Antiviral activities of olomoucine II were tested on a range of human viruses in in vitro assays that evaluated viral growth and replication.

Results

Olomoucine II inhibited replication of a broad range of wild-type human viruses, including herpes simplex virus, human adenovirus type-4 and human cytomegalovirus. Olomoucine II also inhibited replication of vaccinia virus and herpes simplex virus mutants resistant to conventional acyclovir treatment. This report is the first demonstration of a poxvirus being sensitive to a cyclin-de

SUBMITTER: Holcakova J 

PROVIDER: S-EPMC2948526 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature