Improved syntheses of non-dioxin-like polychlorinated biphenyls (PCBs) and some of their sulfur-containing metabolites.

ABSTRACT: Polychlorinated biphenyls (PCBs) are an important group of environmental pollutants that have been associated with adverse human health effects. Despite recent advances in their synthesis, the availability of PCB congeners in sufficient quantity and purity still represents one obstacle in the investigation of their biological effects. We report herein improved syntheses of PCB congeners (and their metabolites) containing two or more ortho-chlorine substituents. The Suzuki coupling reaction at 110 °C yielded PCB congeners with a 2,2'-substitution pattern in good yields (78-99%), but failed to give PCB congeners with 3 or 4 ortho chlorine substituents. Symmetrically substituted PCB congeners with multiple ortho chlorine substituents were obtained in 20-52% yields using a modified Ullmann cou

SUBMITTER: Telu S 

PROVIDER: S-EPMC2948577 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature