A locus for an auditory processing deficit and language impairment in an extended pedigree maps to 12p13.31-q14.3.

ABSTRACT: Despite the apparent robustness of language learning in humans, a large number of children still fail to develop appropriate language skills despite adequate means and opportunity. Most cases of language impairment have a complex etiology, with genetic and environmental influences. In contrast, we describe a three-generation German family who present with an apparently simple segregation of language impairment. Investigations of the family indicate auditory processing difficulties as a core deficit. Affected members performed poorly on a nonword repetition task and present with communication impairments. The brain activation pattern for syllable duration as measured by event-related brain potentials showed clear differences between affected family members and controls, with only affected m

SUBMITTER: Addis L 

PROVIDER: S-EPMC2948670 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature