Kinetic modeling of the serotonin 5-HT(1B) receptor radioligand [(11)C]P943 in humans.

ABSTRACT: [(11)C]P943 is a new radioligand recently developed to image and quantify serotonin 5-Hydroxytryptamine (5-HT(1B)) receptors with positron emission tomography (PET). The purpose of this study was to evaluate [(11)C]P943 for this application in humans, and to determine the most suitable quantification method. Positron emission tomography data and arterial input function measurements were acquired in a cohort of 32 human subjects. Using arterial input functions, compartmental modeling, the Logan graphical analysis, and the multilinear method MA1 were tested. Both the two tissue-compartment model and MA1 provided good fits of the PET data and reliable distribution volume estimates. Using the cerebellum as a reference region, BP(ND) binding potential estimates were computed. [(11)C]P943 BP(ND)

SUBMITTER: Gallezot JD 

PROVIDER: S-EPMC2949107 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature