Genomic instability of I elements of Drosophila melanogaster in absence of dysgenic crosses.

ABSTRACT: Retrotranspostion of I factors in the female germline of Drosophila melanogaster is responsible for the so called I-R hybrid dysgenesis, a phenomenon that produces a broad spectrum of genetic abnormalities including reduced fertility, increased frequency of mutations and chromosome loss. Transposition of I factor depends on cellular conditions that are established in the oocytes of the reactive females and transmitted to their daughters. The so-called reactivity is a cellular state that may exhibit variable levels of expression and represents a permissive condition for I transposition at high levels. Defective I elements have been proposed to be the genetic determinants of reactivity and, through their differential expression, to modulate transposition of active copies in somatic and/or ge

SUBMITTER: Moschetti R 

PROVIDER: S-EPMC2949383 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature