A network of cancer genes with co-occurring and anti-co-occurring mutations.

ABSTRACT: Certain cancer genes contribute to tumorigenesis in a manner of either co-occurring or mutually exclusive (anti-co-occurring) mutations; however, the global picture of when, where and how these functional interactions occur remains unclear. This study presents a systems biology approach for this purpose. After applying this method to cancer gene mutation data generated from large-scale and whole genome sequencing of cancer samples, a network of cancer genes with co-occurring and anti-co-occurring mutations was constructed. Analysis of this network revealed that genes with co-occurring mutations prefer direct signaling transductions and that the interaction relations among cancer genes in the network are related with their functional similarity. It was also revealed that genes with co-occur

SUBMITTER: Cui Q 

PROVIDER: S-EPMC2949398 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature