Survival in critical illness is associated with early activation of mitochondrial biogenesis.

ABSTRACT:

Rationale

We previously reported outcome-associated decreases in muscle energetic status and mitochondrial dysfunction in septic patients with multiorgan failure. We postulate that survivors have a greater ability to maintain or recover normal mitochondrial functionality.

Objectives

To determine whether mitochondrial biogenesis, the process promoting mitochondrial capacity, is affected in critically ill patients.

Methods

Muscle biopsies were taken from 16 critically ill patients recently admitted to intensive care (average 1-2 d) and from 10 healthy, age-matched patients undergoing elective hip surgery.

Measurements and main results

Survival, mitochondrial morphology, mitochondrial protein content and enzyme activity, mitochondrial biogenesis factor mRNA, micro

SUBMITTER: Carre JE 

PROVIDER: S-EPMC2949402 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature