Sleep-disordered breathing and prothrombotic biomarkers: cross-sectional results of the Cleveland Family Study.

ABSTRACT:

Rationale

Individuals with sleep-disordered breathing (SDB) are at increased cardiovascular risk, possibly due to SDB-related stresses contributing to atherosclerosis.

Objectives

We postulate that pathways associated with a prothrombotic potential are up-regulated in SDB.

Methods

Morning and evening plasminogen activator inhibitor-1 (PAI-1), morning fibrinogen, and morning D-dimer were measured in 537 Cleveland Family Study adults. Piecewise multivariable linear mixed models estimated relative mean change or mean change in the biomarker per 5-unit increase in apnea-hypopnea index (AHI) in two groups: AHI less than 15 and AHI greater than or equal to 15, and hypoxia defined as percentage of sleep time with Sa(O(2)) less than 90% (< 2%, ≥ 2%).

Measurements and main r

SUBMITTER: Mehra R 

PROVIDER: S-EPMC2949407 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature