FGF receptors 1 and 2 control chemically induced injury and compound detoxification in regenerating livers of mice.

ABSTRACT:

Background & aims

Fibroblast growth factor receptor 4 (FGFR4) controls bile acid metabolism and protects the liver from fibrosis, but the roles of FGFR1 and FGFR2 in the adult liver are largely unknown. We investigated the functions and mechanisms of action of these receptors in liver homeostasis, regeneration, and fibrosis.

Methods

We generated mice with hepatocytes that lack FGFR1 and FGFR2 and subjected them to acute and chronic carbon tetrachloride-induced liver injury and partial hepatectomy; mice were also injected with FGF7. We performed histology, histomorphometry, real-time reverse transcription polymerase chain reaction, and immunoblot analyses.

Results

In hepatocytes, loss of FGFR1 and FGFR2 eliminated responsiveness to FGF7 and related FGF family members b

SUBMITTER: Bohm F 

PROVIDER: S-EPMC2949525 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature