Columnar cell lesions and subsequent breast cancer risk: a nested case-control study.

ABSTRACT:

Introduction

Histologic and genetic evidence suggests that at least some columnar cell lesions (CCL) of the breast represent precursor lesions in the low-grade breast neoplasia pathway. However, the risk of subsequent breast cancer associated with the presence of CCL in a benign breast biopsy is poorly understood.

Methods

The authors examined the association between the presence of CCL and subsequent breast cancer risk in a nested case-control study of benign breast disease (BBD) and breast cancer within the Nurses' Health Studies (394 cases, 1,606 controls). Benign breast biopsy slides were reviewed by pathologists and CCL presence assessed. Logistic regression was used to compute odds ratios (ORs) and 95% confidence intervals (CIs) for the association between CCL and breas

SUBMITTER: Aroner SA 

PROVIDER: S-EPMC2949654 | biostudies-literature | 2010

REPOSITORIES: biostudies-literature