Low linkage disequilibrium in wild Anopheles gambiae s.l. populations.

ABSTRACT:

Background

In the malaria vector Anopheles gambiae, understanding diversity in natural populations and genetic components of important phenotypes such as resistance to malaria infection is crucial for developing new malaria transmission blocking strategies. The design and interpretation of many studies here depends critically on Linkage disequilibrium (LD). For example in association studies, LD determines the density of Single Nucleotide Polymorphisms (SNPs) to be genotyped to represent the majority of the genomic information. Here, we aim to determine LD in wild An. gambiae s.l. populations in 4 genes potentially involved in mosquito immune responses against pathogens (Gambicin, NOS, REL2 and FBN9) using previously published and newly generated sequences.

Results

The level

SUBMITTER: Harris C 

PROVIDER: S-EPMC2949739 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature