CPP-ZFN: a potential DNA-targeting anti-malarial drug.

ABSTRACT:

Background

Multidrug-resistant Plasmodium is of major concern today. Effective vaccines or successful applications of RNAi-based strategies for the treatment of malaria are currently unavailable. An unexplored area in the field of malaria research is the development of DNA-targeting drugs that can specifically interact with parasitic DNA and introduce deleterious changes, leading to loss of vital genome function and parasite death.

Presentation of the hypothesis

Advances in the development of zinc finger nuclease (ZFN) with engineered DNA recognition domains allow us to design and develop nuclease of high target sequence specificity with a mega recognition site that typically occurs only once in the genome. Moreover, cell-penetrating peptides (CPP) can cross the cell plasma

SUBMITTER: Nain V 

PROVIDER: S-EPMC2949742 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature