Motif prediction to distinguish LPS-stimulated pro-inflammatory vs. antibacterial macrophage genes.

ABSTRACT:

Background

Innate immunity is the first line of defence offered by host cells to infections. Macrophage cells involved in innate immunity are stimulated by lipopolysaccharide (LPS), found on bacterial cell surface, to express a complex array of gene products. Persistent LPS stimulation makes a macrophage tolerant to LPS with down regulation of inflammatory genes ("pro-inflammatory") while continually expressing genes to fight the bacterial infection ("antibacterial"). Interactions of transcription factors (TF) at their cognate TF binding sites (TFBS) on the expressed genes are important in transcriptional regulatory networks that control these pro-inflammatory and antibacterial expression paradigms involved in LPS stimulation.

Results

We used differential expression patterns

SUBMITTER: Kollipara RK 

PROVIDER: S-EPMC2949756 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature