Assessing changes in vascular permeability in a hamster model of viral hemorrhagic fever.

ABSTRACT:

Background

A number of RNA viruses cause viral hemorrhagic fever (VHF), in which proinflammatory mediators released from infected cells induce increased permeability of the endothelial lining of blood vessels, leading to loss of plasma volume, hypotension, multi-organ failure, shock and death. The optimal treatment of VHF should therefore include both the use of antiviral drugs to inhibit viral replication and measures to prevent or correct changes in vascular function. Although rodent models have been used to evaluate treatments for increased vascular permeability (VP) in bacterial sepsis, such studies have not been performed for VHF.

Results

Here, we use an established model of Pichinde virus infection of hamsters to demonstrate how changes in VP can be detected by intrave

SUBMITTER: Gowen BB 

PROVIDER: S-EPMC2949842 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature