Profiling of cellular proteins in porcine reproductive and respiratory syndrome virus virions by proteomics analysis.

ABSTRACT:

Background

Porcine reproductive and respiratory syndrome virus (PRRSV) is an enveloped virus, bearing severe economic consequences to the swine industry worldwide. Previous studies on enveloped viruses have shown that many incorporated cellular proteins associated with the virion's membranes that might play important roles in viral infectivity. In this study, we sought to proteomically profile the cellular proteins incorporated into or associated with the virions of a highly virulent PRRSV strain GDBY1, and to provide foundation for further investigations on the roles of incorporated/associated cellular proteins on PRRSV's infectivity.

Results

In our experiment, sixty one cellular proteins were identified in highly purified PRRSV virions by two-dimensional gel electrophoresi

SUBMITTER: Zhang C 

PROVIDER: S-EPMC2949843 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature