Heptavalent pneumococcal conjugate vaccine immunogenicity in very-low-birth-weight, premature infants.

ABSTRACT:

Background

The heptavalent pneumococcal CRM197 conjugate vaccine (PCV-7) has been incompletely studied in very-low-birth-weight (< or =1500 g) infants.

Objective

To assess PCV-7 immunogenicity in very-low-birth-weight, premature infants. We hypothesized that the frequency of postvaccine antibody concentrations > or =0.15 microg/mL would vary directly with birth weight.

Methods

This was a multicenter observational study. Infants 401 to 1500 g birth weight and <32 0/7 weeks gestation, stratified by birth weight, were enrolled from 9 National Institute of Child Health and Human Development Neonatal Research Network centers. Infants received PCV-7 at 2, 4, and 6 months after birth and had blood drawn 4 to 6 weeks following the third dose. Antibodies against the 7 vaccine

SUBMITTER: D'Angio CT 

PROVIDER: S-EPMC2949965 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature