Targeted interactomics reveals a complex core cell cycle machinery in Arabidopsis thaliana.

ABSTRACT: Cell proliferation is the main driving force for plant growth. Although genome sequence analysis revealed a high number of cell cycle genes in plants, little is known about the molecular complexes steering cell division. In a targeted proteomics approach, we mapped the core complex machinery at the heart of the Arabidopsis thaliana cell cycle control. Besides a central regulatory network of core complexes, we distinguished a peripheral network that links the core machinery to up- and downstream pathways. Over 100 new candidate cell cycle proteins were predicted and an in-depth biological interpretation demonstrated the hypothesis-generating power of the interaction data. The data set provided a comprehensive view on heterodimeric cyclin-dependent kinase (CDK)-cyclin complexes in plants. Fo

SUBMITTER: Van Leene J 

PROVIDER: S-EPMC2950081 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature