Prostate cancer susceptibility variants confer increased risk of disease progression.

ABSTRACT:

Background

Genome-wide association studies have identified numerous single nucleotide polymorphisms (SNP) associated with the risk of prostate cancer. Our objective was to determine whether these SNPs affect the progression of prostate cancer.

Methods

We genotyped 26 SNPs previously associated with prostate cancer risk among 788 aggressive prostate cancer patients who were treated by radical prostatectomy or radiation therapy. Prostate cancer progression was defined as biochemical recurrence based on posttreatment prostate-specific antigen levels of >0.3 ng/mL for radical prostatectomy patients or a 2-ng/mL increase above the nadir for radiation therapy patients, initiation of hormone treatment, or metastases. We assessed the association between independent and combined SNPs

SUBMITTER: Cheng I 

PROVIDER: S-EPMC2950095 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature