A candidate gene study of folate-associated one carbon metabolism genes and colorectal cancer risk.

ABSTRACT:

Background

Folate-associated one-carbon metabolism (FOCM) may play an important role in colorectal carcinogenesis. Variation in FOCM genes may explain some of the underlying risk of colorectal cancer.

Methods

This study utilized data from 1,805 population-based colorectal cancer cases and 2,878 matched sibling controls from the Colon Cancer Family Registry. We used a comprehensive haplotype tagging single nucleotide polymorphism (tagSNP) approach to select 395 tagSNPs in 15 genes involved in folate and vitamin B(12) metabolism. Genotyping was done using the Illumina GoldenGate or Sequenom platforms. Risk factor and dietary data were collected using self-completed questionnaires. Microsatellite instability (MSI) status was determined using standard techniques, and tumor subsi

SUBMITTER: Levine AJ 

PROVIDER: S-EPMC2950115 | biostudies-literature | 2010 Jul

REPOSITORIES: biostudies-literature