A concise synthesis of beta-sitosterol and other phytosterols.

ABSTRACT: A convenient synthesis of sidechain-modified phytosterols is achieved via a temporary masking of the stigmasterol 5,6-alkene as an epoxide. Following performance of the desired modification, the alkene is regenerated through a mild deoxygenation. The approach is applied to the syntheses of beta-sitosterol and campesterol acetate, and suggests a facile route to the (Z)-isomers of Delta(22-23) phytosterols.

SUBMITTER: Hang J 

PROVIDER: S-EPMC2950316 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature