Planarian regeneration involves distinct stem cell responses to wounds and tissue absence.

ABSTRACT: Regeneration requires signaling from a wound site for detection of the wound and a mechanism that determines the nature of the injury to specify the appropriate regenerative response. Wound signals and tissue responses to wounds that elicit regeneration remain poorly understood. Planarians are able to regenerate from essentially any type of injury and present a novel system for the study of wound responses in regeneration initiation. Newly developed molecular and cellular tools now enable study of regeneration initiation using the planarian Schmidtea mediterranea. Planarian regeneration requires adult stem cells called neoblasts and amputation triggers two peaks in neoblast mitoses early in regeneration. We demonstrate that the first mitotic peak is a body-wide response to any injury and t

SUBMITTER: Wenemoser D 

PROVIDER: S-EPMC2950745 | biostudies-literature | 2010 Aug

REPOSITORIES: biostudies-literature