A trial of clarithromycin for the treatment of suboptimally controlled asthma.

ABSTRACT:

Background

PCR studies have demonstrated evidence of Mycoplasma pneumoniae and Chlamydophila pneumoniae in the lower airways of patients with asthma.

Objective

To test the hypothesis that clarithromycin would improve asthma control in individuals with mild-to-moderate persistent asthma that was not well controlled despite treatment with low-dose inhaled corticosteroids.

Methods

Adults with an Asthma Control Questionnaire score ≥1.5 after a 4-week period of treatment with fluticasone propionate were entered into a PCR-stratified randomized, controlled trial to evaluate the effect of 16 weeks of either clarithromycin or placebo, added to fluticasone, on asthma control in individuals with or without lower airway PCR evidence of M pneumoniae or C pneumoniae.

Results

SUBMITTER: Sutherland ER 

PROVIDER: S-EPMC2950827 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature