Ethanol alters the osteogenic differentiation of amniotic fluid-derived stem cells.

ABSTRACT:

Background

Fetal alcohol spectrum disorder (FASD) is a set of developmental defects caused by prenatal alcohol exposure. Clinical manifestations of FASD are highly variable and include mental retardation and developmental defects of the heart, kidney, muscle, skeleton, and craniofacial structures. Specific effects of ethanol on fetal cells include induction of apoptosis as well as inhibition of proliferation, differentiation, and migration. This complex set of responses suggests that a bioinformatics approach could clarify some of the pathways involved in these responses.

Methods

In this study, the responses of fetal stem cells derived from the amniotic fluid (AFSCs) to treatment with ethanol have been examined. Large-scale transcriptome analysis of ethanol-treated AFSCs ind

SUBMITTER: Hipp JA 

PROVIDER: S-EPMC2950880 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature