Plasma and cerebrospinal fluid pharmacokinetics of flurbiprofen in children.

ABSTRACT:

Aims

This study was designed to characterize paediatric pharmacokinetics and central nervous system exposure of flurbiprofen.

Methods

The pharmacokinetics of flurbiprofen were studied in 64 healthy children aged 3 months to 13 years, undergoing surgery with spinal anaesthesia. Children were administered preoperatively a single dose of flurbiprofen intravenously as prodrug (n= 27) or by mouth as syrup (n= 37). A single cerebrospinal fluid (CSF) sample (n= 60) was collected at the induction of anaesthesia, and plasma samples (n= 304) before, during and after the operation (up to 20 h after administration). A population pharmacokinetic model was built using the NONMEM software package.

Results

Flurbiprofen concentrations in plasma were well described by a three compartme

SUBMITTER: Kumpulainen E 

PROVIDER: S-EPMC2950990 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature