Neurotrophic and neuroimmune responses to early-life Pseudomonas aeruginosa infection in rat lungs.

ABSTRACT: Early-life respiratory infection with Pseudomonas aeruginosa is common in children with cystic fibrosis or immune deficits. Although many of its clinical manifestations involve neural reflexes, little information is available on the peripheral nervous system of infected airways. This study sought to determine whether early-life infection triggers a neurogenic-mediated immunoinflammatory response, the mechanisms of this response, and its relationship with other immunoinflammatory pathways. Weanling and adult rats were inoculated with suspensions containing P. aeruginosa (PAO1) coated on alginate microspheres suspended in Tris-CaCl(2) buffer. Five days after infection, rats were injected with capsaicin to stimulate nociceptive nerves in the airway mucosa, and microvascular permeability was m

SUBMITTER: Cardenas S 

PROVIDER: S-EPMC2951071 | biostudies-literature | 2010 Sep

REPOSITORIES: biostudies-literature