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Structural genomics of histone tail recognition.

ABSTRACT:

Summary

The structural genomics of histone tail recognition web server is an open access resource that presents within mini articles all publicly available experimental structures of histone tails in complex with human proteins. Each article is composed of interactive 3D slides that dissect the structural mechanism underlying the recognition of specific sequences and histone marks. A concise text html-linked to interactive graphics guides the reader through the main features of the interaction. This resource can be used to analyze and compare binding modes across multiple histone recognition modules, to evaluate the chemical tractability of binding sites involved in epigenetic signaling and design small molecule inhibitors.

Availability

http://www.thesgc.org/resources/histone_tails/

Contact

matthieu.schapira@utoronto.ca

Supplementary information

Supplementary data are available at Bioinformatics online.

SUBMITTER: Wang M

PROVIDER: S-EPMC2951094 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature

ACCESS DATA

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Publications

Structural genomics of histone tail recognition.

Wang Minghua M Mok Man Wai MW Harper Hong H Lee Wen Hwa WH Min Jinrong J Knapp Stefan S Oppermann Udo U Marsden Brian B Schapira Matthieu M

Bioinformatics (Oxford, England) 20100824 20

<h4>Summary</h4>The structural genomics of histone tail recognition web server is an open access resource that presents within mini articles all publicly available experimental structures of histone tails in complex with human proteins. Each article is composed of interactive 3D slides that dissect the structural mechanism underlying the recognition of specific sequences and histone marks. A concise text html-linked to interactive graphics guides the reader through the main features of the inter ...[more]

PMID: 20739309

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