Synergistic effect of the combination of ranolazine and dronedarone to suppress atrial fibrillation.

ABSTRACT:

Objectives

The aim of this study was to evaluate the effectiveness of a combination of dronedarone and ranolazine in suppression of atrial fibrillation (AF).

Background

Safe and effective pharmacological management of AF remains one of the greatest unmet medical needs.

Methods

The electrophysiological effects of dronedarone (10 μmol/l) and a relatively low concentration of ranolazine (5 μmol/l) separately and in combination were evaluated in canine isolated coronary-perfused right and left atrial and left ventricular preparations as well as in pulmonary vein preparations.

Results

Ranolazine caused moderate atrial-selective prolongation of action potential duration and atrial-selective depression of sodium channel-mediated parameters, including maximal rate of r

SUBMITTER: Burashnikov A 

PROVIDER: S-EPMC2951276 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature