Genetic signatures in the envelope glycoproteins of HIV-1 that associate with broadly neutralizing antibodies.

ABSTRACT: A steady increase in knowledge of the molecular and antigenic structure of the gp120 and gp41 HIV-1 envelope glycoproteins (Env) is yielding important new insights for vaccine design, but it has been difficult to translate this information to an immunogen that elicits broadly neutralizing antibodies. To help bridge this gap, we used phylogenetically corrected statistical methods to identify amino acid signature patterns in Envs derived from people who have made potently neutralizing antibodies, with the hypothesis that these Envs may share common features that would be useful for incorporation in a vaccine immunogen. Before attempting this, essentially as a control, we explored the utility of our computational methods for defining signatures of complex neutralization phenotypes by analyzin

SUBMITTER: Gnanakaran S 

PROVIDER: S-EPMC2951345 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature