H3K27me3 profiling of the endosperm implies exclusion of polycomb group protein targeting by DNA methylation.

ABSTRACT: Polycomb group (PcG) proteins act as evolutionary conserved epigenetic mediators of cell identity because they repress transcriptional programs that are not required at particular developmental stages. Each tissue is likely to have a specific epigenetic profile, which acts as a blueprint for its developmental fate. A hallmark for Polycomb Repressive Complex 2 (PRC2) activity is trimethylated lysine 27 on histone H3 (H3K27me3). In plants, there are distinct PRC2 complexes for vegetative and reproductive development, and it was unknown so far whether these complexes have target gene specificity. The Fertilization Independent Seed (FIS) PRC2 complex is specifically expressed in the endosperm and is required for its development; loss of FIS function causes endosperm hyperproliferation and seed

SUBMITTER: Weinhofer I 

PROVIDER: S-EPMC2951372 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature