Immature and neurally differentiated mouse embryonic stem cells do not express a functional Fas/Fas ligand system.

ABSTRACT: The potential of pluripotent embryonic stem (ES) cells to develop into functional cells or tissue provides an opportunity in the development of new therapies for many diseases including neurodegenerative disorders. The survival of implanted cells usually requires systemic immunosuppression, however, which severely compromises the host immune system, leading to complications in clinical transplantation. An optimal therapy would therefore be the induction of specific tolerance to the donor cells, while otherwise preserving functional immune responses. Fas ligand (FasL) is expressed in activated lymphocytes as well as cells in "immune-privileged" sites including the central nervous system. Its receptor, Fas, is expressed on various immune-reactive cell types, such as activated natural killer

SUBMITTER: Brunlid G 

PROVIDER: S-EPMC2951385 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature