Towards a quantitative understanding of mitotic spindle assembly and mechanics.

ABSTRACT: The 'simple' view of the mitotic spindle is that it self-assembles as a result of microtubules (MTs) randomly searching for chromosomes, after which the spindle length is maintained by a balance of outward tension exerted by molecular motors on the MTs connecting centrosomes and chromosomes, and compression generated by other motors on the MTs connecting the spindle poles. This picture is being challenged now by mounting evidence indicating that spindle assembly and maintenance rely on much more complex interconnected networks of microtubules, molecular motors, chromosomes and regulatory proteins. From an engineering point of view, three design principles of this molecular machine are especially important: the spindle assembles quickly, it assembles accurately, and it is mechanically robus

SUBMITTER: Mogilner A 

PROVIDER: S-EPMC2951465 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature