A role for the dynamin-like protein Vps1 during endocytosis in yeast.

ABSTRACT: Dynamins are a conserved family of proteins involved in membrane fusion and fission. Although mammalian dynamins are known to be involved in several membrane-trafficking events, the role of dynamin-1 in endocytosis is the best-characterised role of this protein family. Despite many similarities between endocytosis in yeast and mammalian cells, a comparable role for dynamins in yeast has not previously been demonstrated. The reported lack of involvement of dynamins in yeast endocytosis has raised questions over the general applicability of the current yeast model of endocytosis, and has also precluded studies using well-developed methods in yeast, to further our understanding of the mechanism of dynamin function during endocytosis. Here, we investigate the yeast dynamin-like protein Vps1 an

SUBMITTER: Smaczynska-de Rooij II 

PROVIDER: S-EPMC2951468 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature