A responsive europium(III) chelate that provides a direct readout of pH by MRI.

ABSTRACT: A europium(III) DO3A-tris(amide) complex is reported for imaging pH by MRI using ratiometric chemical exchange saturation transfer (CEST) principles. Deprotonation of a single phenolic proton between pH 6 and 7.6 results in an ∼5 ppm shift in the water exchange CEST peak that is easily detected by MRI. Collection of two CEST images at two slightly different activation frequencies provides a direct readout of solution pH without the need of a concentration marker.

SUBMITTER: Wu Y 

PROVIDER: S-EPMC2951490 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature