Mn-SOD and CuZn-SOD polymorphisms and interactions with risk factors in gastric cancer.

ABSTRACT:

Aim

To investigate the effects of superoxide dismutase (SOD) polymorphisms (rs4998557, rs4880), Helicobacter pylori (H. pylori) infection and environmental factors in gastric cancer (GC) and malignant potential of gastric precancerous lesions (GPL).

Methods

Copper-zinc superoxide dismutase (SOD1, CuZn-SOD)-G7958A (rs4998557) and manganese superoxide dismutase (SOD2, Mn-SOD)-Val16Ala (rs4880) polymorphisms were genotyped by SNaPshot multiplex polymerase chain reaction (PCR) in 145 patients with GPL (87 cases of gastric ulcer, 33 cases of gastric polyps and 25 cases of atrophic gastritis), 140 patients with GC and 147 healthy controls. H. pylori infection was detected by immunoblotting analysis.

Results

The SOD1-7958A allele was associated with a higher risk of gastric

SUBMITTER: Yi JF 

PROVIDER: S-EPMC2951527 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature