Prediction of functional engrailed homology-1 protein motif from sequence.

ABSTRACT: Prediction of functional peptide motifs from sequences is an important problem in bioinformatics. Experimental discovery of functional sequences is laborious. Searches for specific motifs within the increasing number of proteins available in public databases often involve extensive computer calculations. Short peptide motifs are especially hard to identify via currently available methods. Presented here is a simple and effective procedure to identify a short functional motif. The procedure is based on devising a scoring function using sequence properties. The procedure was applied on short engrailed homology-1 (eh1)-like motif. Eh1-like motif provides repressive functions by binding to the WD domain of the Gro/TLE transcriptional corepressors. Interactions of known eh1-like variants and th

SUBMITTER: Dalafave DS 

PROVIDER: S-EPMC2951711 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature