Relationship between human oral lichen planus and oral squamous cell carcinoma at a genomic level: a datamining study.

ABSTRACT: The leader gene approach is a data mining method based on the systematic search for genes involved in a specific process and their ranking according to the number of interconnections with the other genes identified. The genes with the strongest interconnections are termed leader genes, since they may be supposed to play an important role in the process. The potential of malignant progression of OLP to oral squamous cell carcinoma (OSCC) is still not completely clear. In this study, the leader gene approach is applied to investigate the association between OLP and OSCC at a molecular level. Results were integrated with those obtained in an experimental analysis (see paper 1 of this series). Genes involved in OLP and OSCC were identified by systematic queries to dedicated databases. Intercon

SUBMITTER: Giacomelli L 

PROVIDER: S-EPMC2951714 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature