Ancestral paternal genotype controls body weight and food intake for multiple generations.

ABSTRACT: Current treatments have largely failed to slow the rapidly increasing world-wide prevalence of obesity and its co-morbidities. Despite a strong genetic contribution to obesity (40-70%), only a small percentage of heritability is explained with current knowledge of monogenic abnormalities, common sequence variants and conventional modes of inheritance. Epigenetic effects are rarely tested in humans because of difficulties arranging studies that distinguish conventional and transgenerational inheritance while simultaneously controlling environmental factors and learned behaviors. However, growing evidence from model organisms implicates genetic and environmental factors in one generation that affect phenotypes in subsequent generations. In this report, we provide the first evidence for pater

SUBMITTER: Yazbek SN 

PROVIDER: S-EPMC2951864 | biostudies-literature | 2010 Nov

REPOSITORIES: biostudies-literature