Influenza vaccination, pneumococcal vaccination and risk of acute myocardial infarction: matched case-control study.

ABSTRACT:

Background

Previous studies have shown an association between acute myocardial infarction and preceding respiratory infection. Contradictory evidence exists on the influence of influenza vaccination and pneumococcal vaccination in preventing cardiovascular disease. We aimed to investigate the possible association of influenza vaccination and pneumococcal vaccination with acute myocardial infarction.

Methods

We used a matched case-control design with data from the United Kingdom General Practice Research Database. Cases were patients who were at least 40 years of age at diagnosis of first acute myocardial infarction recorded from Nov.1, 2001, to May 31, 2007, and were matched for sex, general practice, age and calendar time (i.e., month corresponding to index date of acute my

SUBMITTER: Siriwardena AN 

PROVIDER: S-EPMC2952008 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature