Total synthesis of the Aspidosperma alkaloid (±)-subincanadine F via a titanium-mediated intramolecular nucleophilic acyl substitution strategy.

ABSTRACT: The total synthesis of the bridge-fused Aspidosperma indole alkaloid (±)-subincanadine F has been accomplished in seven steps. The synthetic utility of a titanium-mediated intramolecular nucleophilic acyl substitution (INAS) reaction for the construction of the bridge-fused ring system was demonstrated.

SUBMITTER: Cheng X 

PROVIDER: S-EPMC2952173 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature