Genetic polymorphisms in chronic hyperplastic sinusitis with nasal polyposis.

ABSTRACT:

Objectives/hypothesis

Although many proinflammatory cytokines have been identified in nasal polyp tissue, the initial trigger that causes this inflammation characterized by edema, lymphocytosis, and eosinophilia, is still unknown. The purpose of the present study is to identify the presence of genetic polymorphisms in proinflammatory, anti-inflammatory, and chemokine genes that might contribute to genetic susceptibility to chronic hyperplastic sinusitis with nasal polyposis (CHSwNP).

Study design

Case control study.

Methods

Buccal swabs were taken from the left and right oral mucosal surfaces from 179 patients with CHSwNP and 153 nonpolyposis controls with the Purgene DNA purification protocol (Gentra). Genotyping assays for cytokine gene loci were performed on 14 cyt

SUBMITTER: Bernstein JM 

PROVIDER: S-EPMC2952427 | biostudies-literature | 2009 Jul

REPOSITORIES: biostudies-literature