TLRR (lrrc67) interacts with PP1 and is associated with a cytoskeletal complex in the testis.

ABSTRACT:

Background information

Spermatozoa are formed via a complex series of cellular transformations, including acrosome and flagellum formation, nuclear condensation and elongation and removal of residual cytoplasm. Nuclear elongation is accompanied by the formation of a unique cytoskeletal structure, the manchette. We have previously identified a leucine-rich repeat protein that we have named TLRR (testis leucine-rich repeat), associated with the manchette that contains a PP1 (protein phosphatase-1)-binding site. Leucine-rich repeat proteins often mediate protein-protein interactions; therefore, we hypothesize that TLRR acts as a scaffold to link signalling molecules, including PP1, to the manchette near potential substrate proteins important for spermatogenesis.

Results

TLRR an

SUBMITTER: Wang R 

PROVIDER: S-EPMC2952927 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature