Low level anti-Hu reactivity: A risk marker for small cell lung cancer?

ABSTRACT:

Background

Previous experimental and laboratory studies have implicated antibodies against Hu proteins (anti-Hu) as a potential marker for small cell lung cancer (SCLC); there are no estimates of the association between anti-Hu and SCLC using a population-based design.

Methods

We used stored plasma specimens to evaluate anti-Hu reactivity in relationship to small cell lung cancer in a population-based case-control study. Using Western Blot analysis, we measured anti-Hu reactivity against recombinant Hu family member, HuD, in plasma samples from 41 SCLC cases and 79 controls individually matched for age, race, sex, and smoking status (never, past, current). We analyzed the association between anti-Hu reactivity and SCLC using conditional logistic regression.

Results

An

SUBMITTER: Tsou JA 

PROVIDER: S-EPMC2952929 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature