Insights into the MCM functional mechanism: lessons learned from the archaeal MCM complex.

ABSTRACT: The helicase function of the minichromosome maintenance protein (MCM) is essential for genomic DNA replication in archaea and eukaryotes. There has been rapid progress in studies of the structure and function of MCM proteins from different organisms, leading to better understanding of the MCM helicase mechanism. Because there are a number of excellent reviews on this topic, we will use this review to summarize some of the recent progress, with particular focus on the structural aspects of MCM and their implications for helicase function. Given the hexameric and double hexameric architecture observed by X-ray crystallography and electron microscopy of MCMs from archaeal and eukaryotic cells, we summarize and discuss possible unwinding modes by either a hexameric or a double hexameric helica

SUBMITTER: Brewster AS 

PROVIDER: S-EPMC2953368 | biostudies-literature | 2010 Jun

REPOSITORIES: biostudies-literature